Geometric analysis of pathways dynamics: application to versatility of TGF-β receptors

Bibtex

@ARTICLE{Samal2015c,
    author = {Samal, Satya and Naldi, Aur{\'e}lien and Grigoriev, Dima and Weber, Andreas and Th{\`e}ret, Nathalie and
              Radulescu, Ovidiu},
     title = {Geometric analysis of pathways dynamics: application to versatility of TGF-β receptors},
   journal = {Biosystems},
      year = {2016},
     month = jul,
  abstract = {We propose a new geometric approach to describe the qualitative dynamics of chemical reactions
              networks. By this method we identify metastable regimes, defined as low dimensional regions of the
              phase space close to which the dynamics is much slower compared to the rest of the phase space.
              Given the network topology and the orders of magnitude of kinetic parameters, the number of such
              metastable regimes is finite. The dynamics of the network can be described as a sequence of jumps
              from one metastable regime to another. We show that a geometrically computed connectivity graph
              restricts the set of possible jumps. We also provide finite state machine (Markov chain) models for
              such dynamic changes. Applied to signal transduction models, our approach unravels dynamical and
              functional capacities of signaling pathways, as well as parameters responsible for specificity of
              the pathway response. In particular, for a model of TGF$\beta$ signalling, we find that the ratio of
              TGFBR1 to TGFBR2 concentrations can be used to discriminate between metastable regimes. Using
              expression data from the NCI60 panel of human tumor cell lines, we show that aggressive and
              non-aggressive tumour cell lines function in different metastable regimes and can be distinguished
              by measuring the relative concentrations of receptors of the two types.},
       doi = {10.1016/j.biosystems.2016.07.004}
}