Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular Degeneration

Susanne G. Pondorfer, Maximilian Wintergerst, Shekoufeh Gorgi Zadeh, Thomas Schultz, Manuel Heinemann, Frank Holz und Robert Finger
In: Investigative Ophthalmology & Visual Science (März 2020), 61:3(55)
 

Abstract

Purpose: To assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD).

Methods: A total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes from healthy controls) were recruited in this cross-sectional study. All subjects underwent several functional assessments: best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the Pelli–Robson test, reading speed using the International Reading Speed texts, and mesopic and dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence tomography using an approach based on convolutional neural networks. The relationship between drusen volume and visual function was assessed with linear regressions controlling for confounders.

Results: Mean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P < 0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and dark-adapted microperimetry were significantly negatively associated with the overall drusen volume (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid deposits, MAC-VA and mesopic and dark-adapted microperimetry were still significantly associated with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively).

Conclusions: Our results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry, might indicate structural changes related to drusen volume in early stages of AMD.

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Bibtex

@ARTICLE{Pondorfer:2020,
    author = {Pondorfer, Susanne G. and Wintergerst, Maximilian and Gorgi Zadeh, Shekoufeh and Schultz, Thomas and
              Heinemann, Manuel and Holz, Frank and Finger, Robert},
     pages = {55},
     title = {Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular
              Degeneration},
   journal = {Investigative Ophthalmology {\&} Visual Science},
    volume = {61},
    number = {3},
      year = {2020},
     month = mar,
  abstract = {Purpose: To assess which visual function measures are most strongly associated with overall retinal
              drusen volume in age-related macular degeneration (AMD).
              
              Methods: A total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes
              from healthy controls) were recruited in this cross-sectional study. All subjects underwent several
              functional assessments: best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA),
              visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the
              Pelli–Robson test, reading speed using the International Reading Speed texts, and mesopic and
              dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence
              tomography using an approach based on convolutional neural networks. The relationship between drusen
              volume and visual function was assessed with linear regressions controlling for confounders.
              
              Results: Mean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P <
              0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and
              dark-adapted microperimetry were significantly negatively associated with the overall drusen volume
              (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid
              deposits, MAC-VA and mesopic and dark-adapted microperimetry were still significantly associated
              with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively).
              
              Conclusions: Our results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry,
              might indicate structural changes related to drusen volume in early stages of AMD.},
       doi = {10.1167/iovs.61.3.55}
}