4D-CT-based motion correction of PET images using 3D iterative deconvolution

Lena Thomas, Thomas Schultz, Vesna Prokic, Matthias Guckenberger, Stephanie Tanadini-Lang, Melanie Hohberg, Markus Wild, Alexander Drzezga, and Ralph A. Bundschuh
In: Oncotarget (2019), 10:31(2987-2995)
 

Abstract

Objectives: Positron emission tomography acquisition takes several minutes representing an image averaged over multiple breathing cycles. Therefore, in areas influenced by respiratory movement, PET-positive lesions occur larger, but less intensive than they actually are, resulting in false quantitative assessment. We developed a motion-correction algorithm based on 4D-CT without the need to adapt PET-acquisition.

Methods: The algorithm is based on a full 3D iterative Richardson-Lucy-Deconvolution using a point-spread-function constructed using the motion information obtained from the 4D-CT. In a motion phantom study (3 different hot spheres in background activity), optimal parameters for the algorithm in terms of number of iterations and start image were estimated. Finally, the correction method was applied to 3 patient data sets. In phantom and patient data sets lesions were delineated and compared between motion corrected and uncorrected images for activity uptake and volume.

Results: Phantom studies showed best results for motion correction after 6 deconvolution steps or higher. In phantom studies, lesion volume improved up to 23% for the largest, 43% for the medium and 49% for the smallest sphere due to the correction algorithm. In patient data the correction resulted in a significant reduction of the tumor volume up to 33.3 % and an increase of the maximum and mean uptake of the lesion up to 62.1 and 19.8 % respectively.

Conclusion: In conclusion, the proposed motion correction method showed good results in phantom data and a promising reduction of detected lesion volume and a consequently increasing activity uptake in three patients with lung lesions.

Images

Bibtex

@ARTICLE{Thomas:Oncotarget2019,
    author = {Thomas, Lena and Schultz, Thomas and Prokic, Vesna and Guckenberger, Matthias and Tanadini-Lang,
              Stephanie and Hohberg, Melanie and Wild, Markus and Drzezga, Alexander and Bundschuh, Ralph A.},
     pages = {2987--2995},
     title = {4D-CT-based motion correction of PET images using 3D iterative deconvolution},
   journal = {Oncotarget},
    volume = {10},
    number = {31},
      year = {2019},
  abstract = {Objectives:
              Positron emission tomography acquisition takes several minutes representing an image averaged over
              multiple breathing cycles. Therefore, in areas influenced by respiratory movement, PET-positive
              lesions occur larger, but less intensive than they actually are, resulting in false quantitative
              assessment. We developed a motion-correction algorithm based on 4D-CT without the need to adapt
              PET-acquisition.
              
              Methods:
              The algorithm is based on a full 3D iterative Richardson-Lucy-Deconvolution using a
              point-spread-function constructed using the motion information obtained from the 4D-CT. In a motion
              phantom study (3 different hot spheres in background activity), optimal parameters for the algorithm
              in terms of number of iterations and start image were estimated. Finally, the correction method was
              applied to 3 patient data sets. In phantom and patient data sets lesions were delineated and
              compared between motion corrected and uncorrected images for activity uptake and volume.
              
              Results:
              Phantom studies showed best results for motion correction after 6 deconvolution steps or higher. In
              phantom studies, lesion volume improved up to 23% for the largest, 43% for the medium and 49% for
              the smallest sphere due to the correction algorithm. In patient data the correction resulted in a
              significant reduction of the tumor volume up to 33.3 % and an increase of the maximum and mean
              uptake of the lesion up to 62.1 and 19.8 % respectively.
              
              Conclusion:
              In conclusion, the proposed motion correction method showed good results in phantom data and a
              promising reduction of detected lesion volume and a consequently increasing activity uptake in three
              patients with lung lesions.}
}